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DTSTART;TZID=America/New_York:20240426T120000
DTEND;TZID=America/New_York:20240426T130000
DTSTAMP:20260424T112215
CREATED:20240423T204036Z
LAST-MODIFIED:20240423T204036Z
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SUMMARY:Chemical Engineering Spring Seminar Series: Dr. David Brayden
DESCRIPTION:Oral administration of peptides: The quest to improve bioavailability \nThe oral administration of peptides and proteins remains one of the great challenges in pharmaceutical science. Efficacy depends on patients committing to take essential medicines and this is built upon the convenience of a dosing regimen using a patient-friendly route of administration. Large molecules have problems negotiating the GI tract to achieve systemic delivery due to instability against metabolizing enzymes and low permeability across the epithelium. To date\, just five linear peptides aimed at systemic delivery have been approved by the FDA\, the most recent being oral semaglutide (Rybelsus®\, Novo Nordisk\, 2019) and oral octreotide (Mycappsa®\, Chiasma Ltd\, 2020). These approvals heralded a renewed interest in the field\, built around developing Glucagon-1-like peptide 1 (GLP-1) mimetics for Type II diabetes and obesity\, alone or as a dual agonist with other gut peptides. Relative success to date for oral peptides has been achieved with standard oral dosage forms made with permeation enhancers\, but these will only work for niche peptides with high potency and long half-lives. \nMy group has been working on the mechanism of action of the intestinal permeation enhancers that typically are used to enable these formulations\, albeit that oral bioavailability with the above products is less than 1%. We have focussed on comparisons between sodium caprate and SNAC\, both medium-chain fatty acid derivatives\, and found that they have multimodal actions suggesting a dual effects on tight junctions and the intestinal epithelial plasma membrane depending on the concentration and the bioassay. We also have contributed to the search for other permeation enhancers (alone and combination) that can be used with peptides in oral dosage forms including the Gattefosse excipients\, Labrasol® and Labrafac™. We are working on a nanotechnology concept\, where we have achieved 7% bioavailability for insulin in a rat model using a core-shell construct based on silica coating over a core of peptide and the excipients\, L-arginine\, and zinc. Finally\, devices may eventually be able to increase the oral bioavailability of peptides by an order of magnitude over permeation enhancers according to data from animal models\, but clinical testing is at an early stage and the toxicology and the regulatory pathway for these types of technologies have yet to be addressed. I will touch on aspects and examples of these multiple approaches in my talk at Northeastern. \n\nDavid Brayden is Full Professor of Advanced Drug Delivery at the School of Veterinary Medicine and a Fellow of the UCD Conway Institute. Following a Ph.D. in Pharmacology at the University of Cambridge\, UK (1989)\, and a post-doctoral research fellowship at Stanford University\, CA (1991)\, he set up Elan Corporation’s pharmacology laboratory in Dublin (1991). At Elan\, he became a senior scientist and project manager of several of Elan’s Joint-Venture drug delivery research collaborations with US biotech companies. In 2001\, he joined UCD as a college lecturer in veterinary pharmacology and was appointed Senior Lecturer (2005)\, Associate Professor (2006)\, and Full Professor (2014). He completed a successful Principle Investigator Grant from SFI on the topic of oral delivery of novel mucoadhesive polymeric peptide conjugates (2005-2009). Professor Brayden was the Director of an SFI Research Cluster grant (The Irish Drug Delivery Research Network)\, that was awarded 7.2 million euro by SFI from 2007-2013. He was the Deputy Coordinator of an EU 7th Framework grant on oral nanomedicines (www.TRANS-INT.eu)\, 2012-2017. In 2014\, he was one of four Principal Investigators (Co-PIs) on the successful SFI Centre bid in Medical Devices (CURAM)\, worth over 40 million EUR over 6 years\, which was renewed for 6 years in 2021. He is the coordinator of the Horizon Europe consortium grant\, BUCCAL-PEP\, which was awarded 4m EUR and runs from 2022-2026. He is the author or co-author of more than 300 research publications and patents. Professor Brayden serves on the Editorial Advisory Boards of Drug Discovery Today\, Advanced Drug Delivery Reviews and the Journal of Veterinary Pharmacology and Therapeutics. In 2021 he was appointed Chief Editor of “Frontiers in Drug Delivery”. He was Chairman of the UK-Ireland Chapter of the Controlled Release Society (2003-2006)\, Co-Chair of the Veterinary Programmes at the CRS international conferences (2003-2006)\, and served on the CRS Board of Scientific Advisors (2006-2009) and the CRS Annual Meeting Programme Committee (2015\, 2016). At UCD\, he was Chairman of the Animal Research Ethics Committee (2005-2007) and was a member of the UCD Research Ethics Committee (2006-2011) and was elected by Academic Council to the UCD Promotions and Tenure Committee (2010-2012) and to the UCD Academic Council for Academic Centres Committee\, ACCAC (2019-). He was Director of Research for the School of Agriculture\, Food Science and Veterinary Medicine (2007-2008) and Head of the Veterinary Biosciences Section from 2013-2017. On the teaching side\, he coordinates undergraduate and postgraduate modules on Biological Fluids and Drug Discovery and Development and contributes to a module on Cell Communication. He contributes Professional Ethics material to the Conway Institute Core Research Skills modules and also coordinates a 4th level online module on Drug Discovery and Development. In 2015\, he was made an Adjunct Professor at NUI Galway to support his Co-PI role in the SFI CURAM Centre. He was elected as a Fellow of both the Controlled Release Society (2012) and the American Association of Pharmaceutical Scientists (2017). In 2021\, he was appointed by the Minister of Health to the National Research Ethics Committee (Clinical Trials A). He acts as a consultant to selected Pharma and Biotech companies.
URL:https://che.nucoe.madebyvital.com/event/chemical-engineering-spring-seminar-series-dr-david-brayden/
LOCATION:024 East Village\, 360 Huntington Ave\, Boston\, MA\, 02115\, United States
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END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20220223T120000
DTEND;TZID=America/New_York:20220223T130000
DTSTAMP:20260424T112215
CREATED:20220218T181713Z
LAST-MODIFIED:20220218T181713Z
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SUMMARY:Accelerating Research Along the Path to Commercialization
DESCRIPTION:There are a variety of steps required to transition technologies from the research lab to the marketplace. Each step comes with its own set of questions and challenges. How do you protect your innovation and when is the right time? What is the right path to market? What are the obstacles to get there? What resources are available for researchers and entrepreneurs? \nRepresentatives from Northeastern’s Center for Research Innovation (CRI) will help to answer these questions. The CRI is focused on accelerating the advancement of Northeastern research from lab to market\, maximizing its impact\, for the benefit of society. \nTheir talk will be followed by a Q&A session\, providing ample opportunity for researchers to raise any questions and discuss issues related to intellectual property\, technology commercialization\, and entrepreneurship. \nSpeakers:  \nMark Saulich \nAs Associate Director of Commercialization\, Mark and his team are focused on the commercialization of Northeastern research. Industry engagement is at the core of their efforts\, identifying opportunities to solve real world challenges by leveraging Northeastern innovations. Prior to joining the CRI team\, Mark spent several years working at yet2\, a global open innovation consulting company\, leading technology scouting projects for several Fortune 1000 companies. \nKatie Hemphill \nAs Director of Technology Ventures and Talent Network\, Katie leads the development of a pipeline that encourages the discovery\, formation\, launch and growth of new ventures. In addition to managing the various venture programs at CRI\, she continues to cultivate a team of executive talent who mentor and support spinouts as they launch and scale. Prior to joining CRI\, Katie served as Associate Director of the McCarthy(s) Venture Mentoring Network (VMN) at Northeastern’s Center for Entrepreneurship Education at D’Amore-McKim School of Business. The VMN is a global network of volunteer mentors who give time and talent to early-stage startups based on timely business challenges.
URL:https://che.nucoe.madebyvital.com/event/accelerating-research-along-the-path-to-commercialization/
LOCATION:024 East Village\, 360 Huntington Ave\, Boston\, MA\, 02115\, United States
GEO:42.3396156;-71.0886534
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BEGIN:VEVENT
DTSTART;TZID=America/New_York:20220209T120000
DTEND;TZID=America/New_York:20220209T130000
DTSTAMP:20260424T112215
CREATED:20220207T145452Z
LAST-MODIFIED:20220207T145452Z
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SUMMARY:Capture and Conversion of CO2 – Towards CO2 Recycling
DESCRIPTION:ChE Seminar Series Presents: \nJuliana Carnerio\, Ph.D \nPostdoctoral Research Fellow \nSchool of Chemical Engineering & Biomolecular Engineering\, Georgia Institute of Technology \nAbstract: \nOur current global fossil-based economy produces significant environmental\, economic\, and social challenges. Such complex challenges are the defining issues of our time\, pushing society toward stepwise decarbonization of our energy and consumption economy. Ideally\, the aim is a more just and reliable economy\, with minimal social and environmental burdens and the redistribution of economic and environmental benefits. To this end\, a circular carbon economy – which integrates energy\, chemical\, and waste management sectors – offers an opportunity to rethink our linear model. With the CO2 recycling system playing a central role in this proposed model\, the scientific community responds with efforts in R&D to create a suite of CO2 mining and utilization technologies. \nIn the first part of my talk\, I will tackle the electrochemical conversion of CO2 at an elevated temperature regime\, using Reversible Solid Oxide Electrochemical Cells (RSOECs). The optimization of the performance of the oxygen and fuel electrodes in these cells has been hindered by the limited understanding of the factors that govern the O2 and CO2 chemistries. As such\, I will discuss our efforts toward developing design principles for the identification of optimal electrocatalysts for these electrode reactions. We used a combination of theoretical calculations\, controlled synthesis\, advanced characterization\, and testing to show that the binding energy of atomic oxygen can be used as an activity descriptor for these processes. It was found that a compromise in the oxophilicity of the electrocatalyst was required to achieve optimal activity and stability. Our theory-guided design principles successfully identified: (i) Cobalt-doped La2NiO4 as a highly active material for O2 electrocatalysis\, and (ii) Fe\, the most oxophilic metal tested\, as a highly active metal for CO2 electrochemical reduction. However\, Fe exhibited unstable electrochemical behaviors induced by the oxidation of the metal under electrochemical CO2 reduction conditions in SOECs. This phenomenon ratifies the importance of the strength of oxygen binding on the electrocatalyst surface as a descriptor of activity and stability for CO2 electrolysis in SOECs. \nIn the second part of my talk\, I will highlight our work on adsorptive materials for the direct air capture (DAC) of atmospheric CO2. We explore the role of atmospheric humidity as an essential stability parameter for DAC processes employing solid amine adsorbents. We demonstrate this by using prototypical class 1 aminopolymer-type solid sorbents that allow for flexibility in the support use. Sorbent deactivation was investigated by means of several complementary factors\, including (i) the relative loss in amine efficiency determined via time-course CO2 sorption\, (ii) elemental analysis\, and (iii) in situ IR spectroscopy to obtain an understanding of the role of water on the sorbent degradation process. Our findings provide important insights into the relevant parameters that impact the effective design of DAC sorbents and processes for different climatic environments\, allowing tailoring of sorbent formulations to overcome the challenges associated with highly varied conditions in which a DAC process must operate. \nBio: \nDr. Juliana Carneiro is a postdoctoral research fellow in the School of Chemical Engineering & Biomolecular Engineering at the Georgia Institute of Technology with Professor Christopher W Jones. She received her Ph.D. in Chemical Engineering from Wayne State University in 2019 under the supervision of Prof. Eranda Nikolla. Her research interests lie in developing active\, selective\, and stable electrocatalysis for electrochemical conversion and separation processes\, including the electrochemical recycling/upcycling of post-consumer plastics\, the capture and storage of CO2 from oceans\, and the capture and conversion of atmospheric CO2. She is the recipient of several awards\, including\, but not limited to the 2017-2018 Ralph H. Kummler Award for Distinguished Achievement in Graduate Student Research\, 2018 Women’s Initiatives Committee’s (WIC) AIChE Travel Award\, and the prestigious Student Presentation Awards at the (i) Gordon Research Conference on Catalysis\, (ii) the Michigan Catalysis Society.
URL:https://che.nucoe.madebyvital.com/event/capture-and-conversion-of-co2-towards-co2-recycling/
LOCATION:024 East Village\, 360 Huntington Ave\, Boston\, MA\, 02115\, United States
GEO:42.3396156;-71.0886534
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END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20220202T120000
DTEND;TZID=America/New_York:20220202T130000
DTSTAMP:20260424T112215
CREATED:20220120T190612Z
LAST-MODIFIED:20220120T202456Z
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SUMMARY:Platinum: Not as Noble as We Thought
DESCRIPTION:ChE Seminar Series Presents: \nArthur Shih\, Ph.D. \nLeiden Institute of Chemistry\, Leiden University\, The Netherlands \nAbstract \nUnderstanding of catalysis at a fundamental level has historically lagged behind its commercial counterpart with the Haber-Bosch ammonia synthesis process and catalytic converters as pertinent examples [1]. This historical paradigm\, however\, is shifting with the advancement of computing prowess and collaboration. We will discuss how experiments and density functional theory (DFT) computations led us to discover that platinum\, a noble metal that is frequently utilized as a catalyst in the cathode of fuel cells\, restructures when the voltage is held constant between fuel-cell relevant voltages of 0.6 and 1.0 V on a reversible hydrogen electrode scale (VRHE) [2]. \nAn anomalous reduction feature at ~0.53 VRHE was observed on a Pt(111) single crystal in Ar-saturated HClO4 after holding at the fuel-cell relevant voltage of 0.8 VRHE (Figure 1). Decades of research has established that Pt(111) in HClO4 oxidizes H2O to adsorbed *OH between 0.6 and 1.0 VRHE [3-5] and this current model is unable to explain the anomalous feature. Using a combination of computational\, electrochemical\, spectroscopic\, and imaging probes\, we find that holding the voltage between 0.6 and 1.0 VRHE results in a mildly-roughened Pt(111) surface [6]\, presumably due to an *OH-induced release of surface stress. The catalytic performance of this mildly roughened Pt(111) was tested for the oxygen reduction reaction (ORR) and carbon monoxide oxidation (CO Oxidation) where it was found that the ORR rate is seemingly structure insensitive and CO Oxidation rate is surprisingly structure sensitive [7]. Overall\, this discovery demonstrates the importance of understanding how dynamic and steady operating conditions influence the electrode-electrolyte interface – critical for predicting\, designing\, and improving current commercial technologies and opening doors for the development of future technologies. \nBio \nArthur Shih’s research interests are in catalysis for the sustainable production of chemicals and energy\, with emphasis on utilizing reaction kinetics and spectroscopy to understand catalytic mechanisms. He obtained his bachelor’s in Chemical Engineering from the University of Michigan during which he developed computer-based resources with H. Scott Fogler for his textbook “Elements of Chemical Reaction Engineering” and explored several research areas ranging from cancer detection to polymers to CO2 capture. He then earned his Ph.D.\, also in Chemical Engineering\, from Purdue University with Fabio H. Ribeiro where he investigated the thermal-catalytic reduction of toxic nitrogen oxides in catalytic converters. Inspired by the growth and prowess of computational chemistry coupled with a desire to capitalize on cheap renewable electricity for the environment\, he then moved to Leiden University and completed a postdoc in Chemistry with Marc Koper on the electrocatalysis of water splitting to H2 and O2 over well-defined single crystal electrodes. During that time he collaborated with several computational chemists around the world. He is currently a postdoctoral scholar in Materials Science and Engineering at Northwestern University with Sossina Haile working on nitride catalysts for high temperature electrochemical ammonia synthesis. \nIf unable to attend in person\, please contact a.ramsey@northeastern.edu for the link.
URL:https://che.nucoe.madebyvital.com/event/platinum-not-as-noble-as-we-thought/
LOCATION:024 East Village\, 360 Huntington Ave\, Boston\, MA\, 02115\, United States
GEO:42.3396156;-71.0886534
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END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20220126T120000
DTEND;TZID=America/New_York:20220126T130000
DTSTAMP:20260424T112215
CREATED:20220120T190850Z
LAST-MODIFIED:20220120T202413Z
UID:3913-1643198400-1643202000@che.nucoe.madebyvital.com
SUMMARY:Materials Exhibiting Biomimetic Carbon Fixation: Kinetic Analysis\, Mechanistic Insights\, and Material Design
DESCRIPTION:ChE Seminar Series Presents: \nDorsa Parviz\, Ph.D. \nDepartment of Chemical Engineering\, Massachusetts Institute of Technology \n Abstract: \nPopulation growth and climate change necessitate a paradigm shift from current chemical and materials production methods to more sustainable approaches with a negative carbon footprint. In view of this\, I will introduce carbon fixing materials (CFM) as a new synthetic platform that\, like plants\, utilize sunlight to photocatalytically reduce ambient CO2 and add to an ever-extending carbon backbone. First\, I will describe a mathematical framework enveloping the main functions of carbon fixing materials to answer basic questions about the kinetics regimes of operation\, photocatalytic requirements\, and limits of functional materials in CFMs. I will also present mechanistic insights on the photocatalytic reduction of CO2 to C1 intermediates as desired intermediates for producing value-added products from CO2. In the second part of my talk\, I will focus on state-of-the-art 2D nanomaterials and strategies for surface engineering these materials in the colloidal state\, addressing challenges in their characterization for applications in photocatalysis. \nBio: \nDorsa Parviz is a postdoctoral researcher at the Massachusetts Institute of Technology\, working with Prof. Michael Strano in the Department of Chemical Engineering. She earned her Ph.D. in 2016 from Texas A&M University under the guidance of Prof. Micah Green\, where she pioneered techniques for high-yield production of 2D nanomaterials\, investigated their colloidal interactions and assembly\, and designed tailored nanosheet-based polymer composites and 3D networks for structural and electrode applications. During her postdoc\, she developed carbon fixing materials at MIT\, establishing a high-throughput photocatalytic reaction screening system to accomplish this vision. In addition\, she has led the research on the preparation and characterization of biocompatible engineered 2D nanomaterials with tailored structure and properties for nanotoxicity studies at NIEHS Nanosafety Center. \nIf unable to attend in person\, please contact a.ramsey@northeastern.edu for the seminar link.
URL:https://che.nucoe.madebyvital.com/event/materials-exhibiting-biomimetic-carbon-fixation-kinetic-analysis-mechanistic-insights-and-material-design/
LOCATION:024 East Village\, 360 Huntington Ave\, Boston\, MA\, 02115\, United States
GEO:42.3396156;-71.0886534
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